The invention provides a method for treating a microbial infection in an infected subject comprising administering to the subject an antimicrobial composition comprising a therapeutically effective amount of one or more lipophilic cation, and, optionally, another one or more antimicrobial compound or antimicrobial agent. The invention further provides a pharmaceutical composition with antimicrobial properties comprising a therapeutically effective amount of one or more lipophilic cation and another one or more antimicrobial compound or antimicrobial agent.
