Mayo Foundation for Medical Education and Research;The University of Manchester;University Of British Columbia;VIB VZW;Universiteit Antwerpen
发明人:
申请号：
EP13174869.1
公开号：
EP2687223A1
申请日:
2007.05.30
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
