Inhibitors of (2-amino-5, 5-difluor-5, 6-dihydro-4h-[1.3]oxazin-4-il) -phenylamide, Bac 1 and/or Bac2, pharmacological components, preparatory procedures and compounds for the treatment and/or prevention of diseases such as Alzheimer's disease and diabetes.
BANNER DAVID, GUBA WOLFGANG, HILPERT HANS, MAUSER HARALD, MAYWEG ALEXANDER V, NARQUIZIAN ROBERT, PINARD EMMANUEL, POWER
申请号：
CL2012001464
公开号：
CL2012001464A1
申请日:
2012.06.05
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)-phenyl]-amides of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.COMPUESTOS DERIVADOS DE (2-AMINO-5,5-DIFLUOR-5,6-DIHIDRO-4H-[1,3]OXAZIN-4-IL)-FENILAMIDA, INHIBIDORES BACE1 Y/O BACE2； COMPOSICION FARMACEUTICA； PROCEDIMIENTO DE PREPARACION； Y USO EN EL TRATAMIENTO TERAPEUTICO Y/O PROFILACTICO DE ENFERMEDADES TALES COMO ALZHEIMER Y DIABETES.
