Use of a poly(adp-ribose) polymerase (parp) inhibitor in the manufacture of a medicament for treatment of cancer which is deficient in the hr dependent dna dsb repair pathway
THE INSTITUTE OF CANCER RESEARCH; ROYAL CANCER HOSPITAL
发明人:
申请号：
IL17601306
公开号：
IL176013A
申请日:
2006.05.30
申请国别(地区):
IL
年份:
2015
代理人:
摘要：
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.
