The present invention relates to specific binding members which bind to lymphocyte-activation gene 3 (LAG-3). The specific binding members preferably comprise a LAG-3 antigen-binding site which may be located in two or more structural loops of a CH3 domain of the specific binding member. The specific binding members of the invention find application, for example, in cancer therapy.本發明係有關於結合淋巴細胞活化基因3(LAG-3)的專一性結合物件。該專一性結合物件較佳包含一種LAG-3抗原結合位址,其可座落於該專一性結合物件的CH3域之二或更多結構環內。該專一性結合物件於舉例而言,癌症療法方面獲得應用。(無)