Methods and compositions for producing a cellular drug release are disclosed. The method comprises: a) providing a composition comprising a therapeutically effective amount of a pharmacological agent adsorbed onto mesoporous hydroxyapatite (HAP) with hydrophobic surfaces b) exposing the composition to a cell c) causing entry of the mesoporous HAP into the cell and degradation of the HAP in the lysosomes of the cell and desorption of the agent from the mesoporous HAP d) causing release of the desorbed agent from the lysosomes into the cytoplasm of the cell and e) causing release of the desorbed agent to outside the cell. The composition comprises a) mesoporous HAP with hydrophobic surfaces and b) a therapeutically effective amount of a pharmacological agent, adsorbed onto the hydrophobic surfaces of the mesoporous HAP. The composition is characterized in that it constantly releases the agent in vivo for a period of at least 4 weeks.本發明係提供細胞內藥物釋放之組成物及方法。該方法包括:(a)提供一組成物,其包括一治療有效量之藥劑,該藥劑係吸附於具有疏水性表面之中孔徑氫氧基磷灰石(HAP)上;(b)將該組成物暴露至一細胞;(c)使該中孔徑氫氧基磷灰石進入該細胞中並於該細胞之溶酶體中降解,而使該藥劑自該中孔徑氫氧基磷灰石去吸附(desorption);(d)使該經去吸附之藥劑由該溶酶體釋出至該細胞之細胞質中;以及(e)使該經去吸附之藥劑釋出至細胞外。該組成物包括(a)具疏水性表面之中孔徑氫氧基磷灰石(HAP);(b)一治療有效量之藥劑,其係吸附於具有疏水性表面之中孔徑氫氧基磷灰石上。該組成物之特徵為:於生體內持續釋放該藥劑達至少4週。900...藥物投遞系統(組成物)902...中孔徑氫氧基磷灰石904...丙烯酸接枝之中孔徑氫氧基磷灰石905...兩性化合物906...疏水性尾部907...親水性頭部908...藥劑
