Ram VISHWAKARMA,Ajay KUMAR,Inshad Ali KHAN,Sandip Bibishan BHARATE,Prashant JOSHI,Samsher SINGH,Naresh SATTI
申请号：
US15509183
公开号：
US20170273939A1
申请日:
2015.10.21
申请国别(地区):
US
年份:
2017
代理人:
摘要：
A pharmaceutical composition for the treatment of multi-drug resistant infections includes an antimicrobial agent in combination the benzopyrano[3,4-b][1]benzopyran-12(6H)-one class of compound boeravinone B of Formula 1:The bio-efficacy of anti-infective drugs can be potentiated, when used in combination with boeravinone B. Boeravinone B can overcome the resistance or multi-drug resistance developed by bacteria against quinolone, mupirocin and macrolide class of anti-bacterial agents via inhibition of bacterial efflux pumps. Thus, the compositions can be used to treat or prevent drug-resistant bacterial diseases.
