An aqueous ophthalmic composition containing a carbonic anhydrase inhibitor, one or more cellulose derivatives selected from hydroxypropylmethylcellulose acetate succinate and carboxymethylethylcellulose, and water.一種眼科用水性組成物,其含有碳酸酐酶抑制劑、選自羥丙基甲基纖維素醋酸酯琥珀酸酯及羧甲基乙基纖維素之1種以上的纖維素衍生物、及水。