[Object] To obtain an anti-integrin .alpha.8.beta.1 antibody which binds tointegrin .alpha.8B1derived from mammals of different species. Also, to obtain an anti-integrin.alpha.8.beta.1 antibody which inhibits binding between integrin.alpha.8.beta.1 and its ligand.[Solution] Anti-integrin .alpha.8.beta.1 antibodies which bind to integrin.alpha.8.beta.1 derivedfrom mammals of different species have been obtained. In addition,inhibitors, which contain an anti-integrin .alpha.8.beta.1 antibody, ofbinding betweenintegrin .alpha.8.beta.1 and its ligand have been obtained.
