A multi-layer wound dressing includes a base layer with a circumscribing web of material defining a central opening of sufficient size to expose a wound area. An intermediate layer is the bandage layer that is placed over the opening in the base layer. An outer cover layer located above and over the bandage layer makes a sealing connection with the base layer and totally covers the intermediate bandage layer, providing sealing for the wound area and easy and repeated replacement of the bandage layer.