ALLAN, Christine Elizabeth,BATT, Andrzej Roman,DAVIE, Rebecca Louise,EDWARDS, Hannah Joy,EVANS, David Michael,PETHEN, Stephen John
申请号：
ES14700111
公开号：
ES2623895T3
申请日:
2014.01.08
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** in which V is selected from C and N, such that the aromatic ring containing V and s phenyl or pyridine； R2 is absent when V is N； or, when present, R2 is selected from H, alkyl, alkoxy, CN, halo and CF3； R1 and R3 are independently selected from H, alkyl, alkoxy, CN, halo and CF3； W, X, Y and Z are independently selected from C, N, O and S, so that the ring containing W, X, Y and Z is a five-membered aromatic heterocycle； wherein R5, R6 and R7 are independently absent or independently selected from H, alkyl, halo, aryl, heteroaryl and CF3； P is -C (R10) (R11) NH2； R8 and R9 are independently selected from H and alkyl, or together they can form a cycloalkyl ring； R10 and R11 are independently selected from H and alkyl, or together they can form a cycloalkyl ring or a cyclic ether； A is selected from N-linked morpholine, aryl, heteroaryl, alkyl is a linear saturated hydrocarbon having up to 10 carbon atoms (C1-C10) or a branched saturated hydrocarbon of between 3 and 10 carbon atoms (C3-C10)； alkyl may be optionally substituted with 1 or 2 substituents independently selected from (C1-C6) alkoxy, OH, CN, CF3, -COOR12, -CONR12R13, H (CH2) 1-3CON (R12) (CH2) 1-3- , fluorine and -NR12R13； cycloalkyl is a monocyclic saturated hydrocarbon of between 3 and 7 carbon atoms； wherein cycloalkyl may be optionally substituted with a substituent selected from alkyl, alkoxy and NR12R13； a cyclic ether is a saturated monocyclic hydrocarbon of between 4 and 7 carbon atoms, in which one of the ring carbons is replaced by an oxygen atom； alkoxy is a linear hydrocarbon linked to O of 1 to 6 carbon atoms (C1-C6) or a branched hydrocarbon linked to O of 3 to 6 carbon atoms (C3-C6)； Alkoxy may be optionally substituted with 1 or 2 substituents independently selected from OH, CN, CF3, -COOR12, -CONR12R13, fluorine and NR12R13； aryl is phenyl, biphenyl or naphthyl； aryl may be optionally substituted with 1, 2 or 3 substituents independently selected fro
