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CYTOTOXICITÉ ACCRUE DES ANTICORPS ANTI-CD74 ET ANTI-HLA-DR AVEC L'INTERFÉRON GAMMA
专利权人:
IMMUNOMEDICS, INC.;CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY
发明人:
BURTON, JACK D.,STEIN, RHONA,GOLDENBERG, DAVID M.
申请号:
EP11732303
公开号:
EP2523680A4
申请日:
2011.01.11
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Disclosed herein are methods and compositions comprising interferon-γ (IFN-γ) and anti-CD74 or anti-HLA-DR antibodies. In preferred embodiments, the IFN-γ increases the expression of CD74 and/or HLA-DR in target cells and increases the sensitivity of the cells to the cytotoxic effects of the anti-CD74 or anti-HLA-DR antibodies. The compositions and methods are of use to treat diseases involving CD74+ and/or HLA-DR+ cells, such as cancer cells, autoimmune disease cells or immune dysfunction disease cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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