Provided is a portable ventilator system, including a ventilator supply system having a ventilator mask, an air/oxygen source and an air/oxygen regulator system, and including a communications device that, during use, automatically contacts an emergency response entity in response to activation of the portable ventilator system. Also provided is a ventilator system that includes at least one ventilator mask sized to fit upon a selected range of sizes of human faces, a ventilator supply system having an air/oxygen source and an air/oxygen regulator system, and an air/oxygen flow regulation valve having an inlet, an inlet/outlet in communication with a ventilator mask coupled to the ventilator supply system, and an outlet in communication with a surrounding atmosphere. During use, air/oxygen flows through the inlet and the inlet/outlet to facilitate ventilation of a human, and air/oxygen flows through the inlet/outlet and the outlet to facilitate exhalation by a human to the surrounding atmosphere. Further, during use, one of the ventilator masks is coupled to the ventilator supply system to provide air/oxygen to a human, and the air/oxygen regulator system regulates air/oxygen flow parameters as a function of a size of the ventilator mask coupled to the ventilator supply system.