Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses therefor

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专利权人:

Alan S. Verkman;Nitin D. Sonawane

发明人:

Alan S. Verkman,Nitin D. Sonawane

申请号：

US11960521

公开号：

US08552067B2

申请日:

2007.12.19

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Provided herein are bioactive agents comprising a compound that inhibits the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR) and that is linked to a macromolecule that interacts with a cell that expresses CFTR. The bioactive agents described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea.

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中国工程科技知识中心

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http://www.ckcest.cn/home/