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СПОСОБ ПОЛУЧЕНИЯ 5-ХЛОР-N-(5S)-2-ОКСО-3-[4-(3-ОКСО-МОРФОЛИНИЛ)-ФЕНИЛ]-1,3-ОКСАЗОЛИДИН-5-ИЛ}-МЕТИЛ)-2-ТИОФЕНКАРБОКСАМИДА В МОДИФИКАЦИИ II (ВАРИАНТЫ)
专利权人:
BAJER INTELLEKTUEL PROPERTI GMBKH
发明人:
GRUNENBERG ALFONS,ГРУНЕНБЕРГ Альфонс,LENTS JANA,ЛЕНЦ Яна,BRAUN GERKHARD ARNOLD,БРАУН Герхард Арнольд,KAJL BIRGIT,КАЙЛЬ Биргит,TOMAS KRISTIAN,ТОМАС Кристиан
申请号:
RU2011115874/04
公开号:
RU0002578602C2
申请日:
2006.09.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to method for obtaining 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, represented by formula,in modification II (thereof versions). Method for obtaining formula (I) in modification II, characterised by the following spectral data in nearest IR region [cm-1]: 4086, 4228, 4418, 4457, 4634, 4905, 5846, 5911, 6026, 6081, 6582, consists in the fact that compound of formula (I) in modification I, characterised by the following spectral data in nearest IR region [cm-1]: 4082, 4142, 4170, 4228, 4299, 4376, 4429, 4479, 4633, 4791, 4877, 4907, 5081, 5760, 5885, 6002, 6441, 6564, 8473, 8833, is dissolved in inert solvent, selected from the group, including acetone, tetrahydrofuran, 1-pentanol and their mixtures, and compound is precipitated by addition of n-heptane additive at temperatures within from 0 to 80°C. Method for obtaining compound of formula (I) in modification II, is also realised by dissolution of compound (I) in modification I in 1,4-dioxane, with exposure of solution at temperature within from 30°C to temperature of solvent reflux till complete solvent evaporation. Method for obtaining compound of formula (I) in modification II is realised by suspending compound (I) in modification I in ethanol with mixing or shaking suspension at temperature within from 20 to 25°C until transformation into modification II occurs.EFFECT: obtaining 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophenecarboxamide, represented by formula,in modification II, possessing high solubility.4 cl, 12 dwg, 7 tbl, 2 exИзобретение относится к способу получения 5-xлop-N-({(5S)-2-оксо-3-[4-(3-оксо-4-морфолинил)-фенил]-1,3-оксазолидин-5-ил}метил)-2-тиофенкарбоксамида, представленного формулой I, в модификации (II) (его вариантам). Способ получения соединения формулы (I) в модификации II, характеризующейся следующими спектральными данными в б
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