A system to produce a replacement anatomical structure, comprising: a quantitative three-dimensional (Q3D) endoscope disposed to image a structure within a field of view that includes target tissue； at least one processor configured to: produce a first Q3D model of an anatomical structure that includes target tissue； produce a second Q3D model of the anatomical structure that includes remainder tissue in a location from which the target has been tissue removed； and produce a third Q3D model of a replacement structure based at least in part upon the first Q3D model and the second Q3D model.
