UTILISATION DE 5-FLUORO-4-(4-FLUORO-2-METHOXYPHENYL)-N-{4-[(S-METHYLSULFONIMIDOYL)METHYL]PYRIDIN-2-YL}PYRIDIN-2-AMINE POUR TRAITER UN LYMPHOME DIFFUS A GRANDES CELLULES B

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专利权人:

BAYER AKTIENGESELLSCHAFT;BAYER PHARMA AKTIENGESELLSCHAFT

发明人:

SCHOLZ, ARNE

申请号：

CA3090843

公开号：

CA3090843A1

申请日:

2019.02.12

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention relates to the use of 5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S- methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2-amine (compound A), more particularly (+)5- Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-{4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl}pyridin-2- amine (compound A´), for treating diffuse large B-cell lymphoma (DLBCL), especially in germinal- centre B-cell type of diffuse large B-cell lymphoma and especially in diffuse large B-cell lymphoma which cells have an amplification or translocation of the MYC gene and/or BCL2 gene and/or an overexpression of MYC and/or BCL2.

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