Oral Tablet comprising acid compound 1, 3 - (4 - (1 - (2,2 - difluorobenzo [d] [1,3] dioxol - 5 - il) ciclopropanocarboxamido) - 3 - metilpiridin - 2 - yl) benzoic acid in their Crystalline forms and other Therapeutic agent； Preparation Process； Pharmaceutical Kit, method for treat a disease as FIBRO SIS pancreatitis, cystic, Asthma, Epilepsy, among other.

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专利权人:

VERTEX PHARMACEUTICALS INCOPORATED

发明人:

VERMIJIS, MARINUS, JACOBUS

申请号：

CL2014001979

公开号：

CL2014001979A1

申请日:

2014.07.25

申请国别(地区):

CL

年份:

2015

代理人:

摘要：

A pharmaceutical composition comprising Compound 1, (3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid), and at least one excipient selected from: a filler, a disintegrant, a surfactant, a binder, and a lubricant, the composition being suitable for oral administration to a patient in need thereof to treat a CFTR mediated disease such as Cystic Fibrosis. Processes of preparing pharmaceutical compositions comprising Compound 1 are also disclosed.TABLETA ORAL QUE COMPRENDE 3-(6-(1-(2,2-DIFLUOROBENZO [d][1,3] DIOXOL-5-ILO), SUS FORMAS CRISTALINAS I Y II Y/O LA FORMA A DE LA SAL HCl DE DICHO COMPUESTO； KIT FARMACÉUTICO, Y SU USO PARA TRATAR FIBROSIS QUÍSTICA, ASMA, COPD INDUCIDA POR EL HUMO DEL TABACO, DEFICIENCIAS DE PROCESAMIENTO DE LÍPIDOS, DIABETES MELLITUS, ENTRE OTRAS.

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