A pharmaceutical formulation comprises a pharmaceutically acceptable preservative and a material selected from the group consisting of D-glucose, sucrose, maltose, D-mannose, trehalose, glutamic acid, mixtures thereof, and combinations thereof, wherein the formulation has enhanced preservative efficacy against spore-forming microorganisms. The formulation can further comprise boric acid and/or phosphate. A method for enhancing the preservative efficacy of a pharmaceutical formulation against spore-forming microorganisms, comprising adding a pharmaceutically acceptable preservative, and a material selected from the group consisting of D-glucose, sucrose, maltose, D-mannose, trehalose, glutamic acid, mixtures thereof, and combinations thereof, to the pharmaceutical formulation. The formulation optionally includes an active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.本發明係關於醫藥調配物，其包含醫藥上可接受之防腐劑及選自由D-葡萄糖、蔗糖、麥芽糖、D-甘露糖、海藻糖、麩胺酸、其混合物及其組合組成之群之材料，其中該調配物具有提高之對抗孢子形成微生物之防腐效能。該調配物可進一步包含硼酸及/或磷酸鹽。本發明亦係關於用於提高醫藥調配物對抗孢子形成微生物之防腐效能之方法，其包含向該醫藥調配物中添加醫藥上可接受之防腐劑及選自由D-葡萄糖、蔗糖、麥芽糖、D-甘露糖、海藻糖、麩胺酸、其混合物及其組合組成之群之材料。該調配物視情況包括用於治療或控制眼部疾病或病症之活性劑。該調配物可用於治療、清潔、消毒、儲存、潤濕或再潤濕隱形眼鏡。
