IMMUNOCONJUGUES MUTANTS D'IL2 ET DE TNF

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专利权人:

PHILOGEN S.P.A.

发明人:

NERI, DARIO,DE LUCA, ROBERTO,WULHFARD, SARAH

申请号：

CA3043146

公开号：

CA3043146A1

申请日:

2017.11.08

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present application relates to conjugates comprising interleukin 2 (IL2), and a mutant of tumour necrosis factor, such as tumour necrosis factor alpha (TNFa), and an antibody molecule. The antibody molecule preferably binds to an antigen associated with neoplastic growth and/or angiogenesis, such as the Extra-Domain A (EDA) or Extra-Domain B (EDB) of fibronectin. The conjugate may be used in the treatment of cancer.

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