The method described herein for being polymer nano granules and manufacturing and using such treatment nano particle, these polymer nano granules include therapeutic agent, which is 2- (3- ((7- (3- (ethyl (2- ethoxy) amino) propoxyl group) quinazoline -4- base) amino) -1H- pyrazoles -5- base)-N- (3- fluorophenyl) acetamide (also referred to as AZD1152hqpa) or its pharmaceutically acceptable salt.在此描述的是聚合物納米顆粒以及製造和使用此類治療性納米顆粒的方法,這些聚合物納米顆粒包括治療劑,該治療劑是2‑(3‑((7‑(3‑(乙基(2‑羥乙基)氨基)丙氧基)喹唑啉‑4‑基)氨基)‑1H‑吡唑‑5‑基)‑N‑(3‑氟苯基)乙酰胺(也稱爲AZD1152hqpa)或其藥學上可接受的鹽。