<;P>;PROBLEM TO BE SOLVED: To provide a means effective to prevention and treatment for aging deafness, noise deafness, or ear noises. <;P>;SOLUTION: A preventive and therapeutic agent for aging deafness, noise deafness, or ear noises contains a material increasing expression of an endothelin receptor B. Luteolin is preferably used as the material increasing expression of the endothelin receptor B. <;P>;COPYRIGHT: (C)2011,JPO&INPIT