Roman R. Ganta,Chuanmin Cheng,Arathy D. S. Nair,Deborah Jaworski,Suhasini Ganta
申请号：
US16106546
公开号：
US10434161B2
申请日:
2018.08.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the organism to achieve the desired immunity through the modification of a novel genetic region involved in pathogenesis. These compounds represent a needed vaccine against an organism causing life-threatening febrile illness in humans and animals, and also represent the potential to develop new classes of drugs targeting the gene products of genes Ech_0660, Ech_0379, and Ech_0230, and their homologs of other related rickettsial pathogens.
