A surgical stapler (900) having a remote motorized staple head (908) is provided and generally includes a handle (902) having a control button (924) and a highly flexible cable (904) extending distally from the handle. A housing (906) incorporating a staple assembly (908) is affixed to a distal end of the flexible cable. The housing may incorporate articulating structure (1120) to position the staple assembly relative to the remainder of the housing.