System and method help to manage a kind of user of chronic disease, such as chronic respiratory or heart disease. The system may include that physiological monitor is suitable for being carried by user, can effectively detect the physiological parameter of user by generating one or more signals. The system may include that the physiology managing device being operatively coupled receives (multiple) signal and derived physiological parameter (multiple) user. Managing device, such as includes the parameter that processor can be configured to analysis physiology and/or environmental parameter detection triggering pattern, and triggering pattern indicates the chronic respiratory and/or heart of the deterioration of probable event. The then instruction based on triggering pattern that managing device can automated to respond to, such as offer activity and/or treatment chronic condition are provided.