The invention relates to peptides of general formula (I): R1-AA-R2(I)which can regulate neuronal exocytosis, their stereoisomers and racemic or non-racemic mixtures thereof, and the cosmetically or pharmaceutically acceptable salts thereof, wherein AA is a sequence of 3 to 40 adjacent amino acids contained in the amino acid sequence of the SNAP-25 protein, R1is selected from the group consisting of H or alkyl, aryl, aralkyl or acyl group； and R2is selected from the group consisting of amino, hydroxyl or thiol, substituted or non-substituted with aliphatic or cyclic groups, with the condition that when R1is H or acetyl, R2is not non-substituted amino, hydroxyl or thiol. The invention also relates to a method of obtaining such peptides, cosmetic or pharmaceutical compositions containing them and their use to treat those conditions requiring neuronal exocytosis regulation, preferably for treating the skin.本發明關於可調節神經元胞吐之通式(I)的肽類、它們的立體異構物及彼等之消旋或非消旋混合物，及彼等之美容或醫藥上可接受之鹽類：R1-AA-R2(I)其中AA係3至40個包含於SNAP-25蛋白質之胺基酸序列中的相鄰胺基酸序列，R1係選自H或烷基、芳基、芳烷基或醯基；及R2係選自經脂肪族或環狀基團取代或未經取代之胺基、羥基或硫醇基，唯其當R1係H或乙醯基時，R2不是未經取代之胺基、羥基或硫醇基。本發明亦關於一種取得該肽類之方法、包含該肽類之美容或醫藥組成物及它們用於治療該些需要神經元胞吐調節之狀況的用途，較佳係用於治療皮膚。
