Composition and vaccine the present invention provides the varicellazoster virus of inactivation (VZV) and comprising the inactivation VZV, wherein the infectivity of the inactivation VZV can't detect, and wherein the inactivation VZV induces the immune response for VZV when applying what patient. In the embodiment of compositions described herein, VZV γ radiological inactivation. The present invention also provides the methods of preparation inactivation VZV vaccine, and the method includes including the sample of VZV come γ radiation with the γ of about 5kGy to about 50kGy radiation. Relevant other diseases are re-activated the present invention also provides treatment HZ or to VZV or for its immune method, the method includes vaccine or pharmaceutical composition are applied what subject, the vaccine or composition include the inactivation VZV and pharmaceutically acceptable carrier of therapeutically effective amount, wherein the VZV is by γ radiological inactivation.本發明提供了滅活的水痘帶狀疱疹病毒(VZV)和包含所述滅活VZV的組合物和疫苗，其中所述滅活VZV的感染性是檢測不到的，並且其中所述滅活VZV當施用於患者時誘導針對VZV的免疫應答。在本文描述的組合物的實施方案中，所述VZV是用γ輻射滅活的。本發明還提供了製備滅活VZV疫苗的方法，所述方法包括用約5kGy至約50kGy的γ輻射來γ輻射包含VZV的樣品。本發明還提供了治療HZ或與VZV再活化相關的其他疾病或針對其免疫的方法，所述方法包括將疫苗或藥物組合物施用於受試者，所述疫苗或組合物包含治療有效量的滅活VZV和藥學上可接受的載體，其中所述VZV是通過γ輻射滅活的。
