Sphaeranthus indicus and Piper nigrum has been traditionally reported to exhibit a variety of biological activities, including antidiabetic anti- inflammatory and antimicrobial etc. The objective of this study was to evaluate their pharmacological activity against migraine. In present study 5 gm of aqueous extract of whole plant (leaves, flower, roots and fruit) Sphaeranthus indicus and fruit of Piper nigrum formulated in the ratio of 4:1 were given to the patient in the form of tea. The result of present study verifies the effect of extract on permanent cure of migraine in 7 days in the patient who were suffering from migraine disease more than 12 years and no side effect on their health has been reported.
