Incorporating first/second ADCs A1/A2 of an ANR circuit, first/second pluralities P1/P2 of digital filters of a quantity specified by first/second sets S1/S2 of ANR settings, and DACs into first/second pathways Pa1/Pa2; selecting a type of digital filter specified by S1 for each digital filter of P1/P2; adopting a signal processing topology specified by S1 by configuring interconnections among at least A1/A2, P1/P2 and the DAC so that digital data representing sounds flows through Pa1 from A1 to the DAC through at least P1; digital data representing sounds flows through Pa2 from A2 to the DAC through at least P2; Pa1/Pa2 are combined at first/second locations along Pa1/Pa2 such that the digital data are combined before flowing to the DAC; configuring each digital filter with filter coefficients specified by S1; setting a data transfer rate at which digital data flows through at least a portion of Pa1/Pa2 as specified by S1; operating A1/A2, P1/P2 and the DAC to provide ANR in the earpiece; changing an ANR setting specified by S1 to one specified by S2 in synchronization with a transfer of digital data along at least a portion of Pa1/Pa2; monitoring a characteristic of a sound represented by digital data; wherein changing an ANR setting occurs in response to a change in the characteristic, changing an interconnection of the signal processing topology defined by S1, a selection of a digital filter specified by S1, a filter coefficient specified by the S1, and a data transfer rate specified by S1.