KWON, HYUK JOONKR,권혁준,KIM, JAE HONGKR,김재홍,KIM, IL HWANKR,김일환
申请号：
KR1020150180490
公开号：
KR1020160073343A
申请日:
2015.12.16
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a H1N1-based avian influenza virus highly replicative in an embryonated egg and avirulent in a mouse, a composition for manufacturing the virus, a manufacturing method of the virus, an avian influenza virus vaccine comprising the virus as an effective component, and a composition comprising an antiserum against the virus for diagnosing an avian influenza virus. The composition for manufacturing a H1N1-based avian influenza virus highly replicative in an embryonated egg and avirulent in a mouse comprises: a polynucleotide coding hemagglutinin (HA), and a polynucleotide coding neuraminidase of a mutant of a H5N1 virus highly replicative in an embryonated egg a polynucleotide coding polymerase basic protein 2 (PB2) of a low pathogenic avian influenza a polynucleotide coding a polymerase basic protein 1 (PB1), a polynucleotide coding polymerase subunit A (PA), a polynucleotide coding nucleoprotein (NP), a polynucleotide coding a matrix protein (M), and a polynucleotide coding nonstructural protein (NS) of a H1N1-based avian influenza virus.COPYRIGHT KIPO 2016본 발명은 발육란 고증식성 및 마우스 무병원성 H1N1 계통 조류 인플루엔자 바이러스, 상기 바이러스 제조용 조성물, 상기 바이러스 제조방법, 상기 바이러스를 유효성분으로 함유하는 조류 인플루엔자 바이러스 백신, 및 상기 바이러스에 대한 항혈청을 유효성분으로 포함하는 조류 인플루엔자 바이러스 진단용 조성물에 관한 것이다.
