FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to pediatrics, pediatric gastroenterology and hepatology, and can be used for early and accurate diagnosis of liver damage manifested by cholestasis in children of the first months of life. For differential diagnosis of congenital cholestatic diseases in infants with prolonged jaundice in the neonatal period, which is accompanied by hypo- or achiolia of the stool, and / or hepato- or hepatosplenomegaly, perform hepatobiliary scintigraphy with the determination of the time of maximum accumulation (Tmax) of the radiopharmaceutical in the liver, the elimination half-life (T1/2) of RFP from the liver and the time of RFP entering the intestine. Additionally, biochemical blood test is performed to determine the level of gamma-glutamyltranspeptidase (GGTP), total bilirubin and its fractions and alanine aminotransferase (ALT). Depending on the results of the conducted studies, based on the set of established diagnostic criteria, differential diagnosis o
