A method of occluding a defect in a patient is provided. The method includes inserting a placement member, such as a wire guide, into a defect advancing the placement member to a desired location inserting the placement member into a lumen in an occluding member, such as a plug or a graft and advancing the occluding member to the desired location by inserting the placement member into a lumen in a pusher member and pushing the occluding member with the pusher member until the occluding member reaches the desired location. Medical devices and systems for occluding defects are also provided.