B. K. Shanthaveerappa;Kyeong Lee;Xuejun Jin;Young-Soo Hong;Jin Hwan Kim;Jeong-Hyung Lee;Yinlan Jin;Jung Joon Lee
发明人:
Jung Joon Lee,Jeong-Hyung Lee,Kyeong Lee,Young-Soo Hong,B. K. Shanthaveerappa,Yinlan Jin,Jin Hwan Kim,Xuejun Jin
申请号：
US12306319
公开号：
US08394799B2
申请日:
2007.07.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed herein are an HIF-1 inhibitor, a method for the preparation thereof, and a pharmaceutical composition comprising the same as an active ingredient. The HIF-1 inhibitor shows anticancer activity thanks to the inhibition activity against HIF-1, a transcription factor which plays an important role in the growth and metastasis of cancer, but not to general cytotoxicity. Thus, the HIF-inhibitor and a pharmaceutically acceptable salt thereof can be used as a therapeutic for various cancers such as liver cancer； stomach cancer and breast cancer. Also, the compound having inhibition activity against HIF-1 is useful in the treatment of diabetic retinopathy and arthritis, which are aggravated by HIF-1-mediated VEGF expression.
