VARIANT D'IL-2

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专利权人:

KYOWA HAKKO KIRIN CO.; LTD.

发明人:

IKEDA, MASAHIRO,YAMAGUCHI, SHINPEI,MURAKAMI, MASUMI,ONODERA, HIDEYUKI

申请号：

CA3086842

公开号：

CA3086842A1

申请日:

2018.12.27

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The purpose of the present invention is to provide a novel IL-2 variant that has an improved selectivity for IL-2Raß? and selectively activates Treg. The present invention pertains to: an IL-2 variant； a method for producing the IL-2 variant； a composition containing the IL-2 variant； a therapeutic agent for an immunological disease containing the IL-2 variant； a method for elevating the selectivity of IL-2 for IL-2Raß?； a method for improving the affinity of IL-2 for IL-2Ra subunit； a method for lowering the affinity of IL-2 for IL-2Rß and/or ? subunits； and a method for selectively activating a regulatory T cell.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/