Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity

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专利权人:

Bin Yang;Richard D. Dimarchi;Chenguang Ouyang

发明人:

Richard D. Dimarchi,Bin Yang,Chenguang Ouyang

申请号：

US12740206

公开号：

US08980830B2

申请日:

2008.10.27

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.

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中国工程科技知识中心

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http://www.ckcest.cn/home/