GAETANO BRAMBILLA,ROBERT JOHNSON,DAVID ANDREW LEWIS
申请号：
MX2015002027
公开号：
MX2015002027A
申请日:
2013.08.23
申请国别(地区):
MX
年份:
2015
代理人:
摘要：
The invention deals with an actuator (1) for an aerosol inhalation device comprising a housing adapted to receive an aerosol canister (2) containing a pressurised medicament formulation, a mouthpiece portion through which the user inhales, a nozzle block (5), an orifice (8), and a tubular element (11) extending in the mouthpiece portion from the orifice aperture in a longitudinal axis aligned with a longitudinal axis of the mouthpiece portion. In particular said tubular element is positioned to enclose the orifice aperture within a recess. The tubular element is configured such that one of its terminal openings may be close fit to the nozzle block external surface, around the orifice aperture, so as to be in a continuous flow path with the orifice. Such configuration provides for a significant reduction in the non-respirable, coarse fraction of the emitted aerosol medicament via inertial impaction and retention in the actuator than in the oro-pharynx, with consequent less associated side effects and oral candidiasis in the patient. The presence of the tubular element has minimal, negligible impact on the fine particle dose and on the particle size distribution (PSD) of the delivered particles having aerodynamic diameter lower than 9 μm.La presente invención se refiere a un actuador (1) de un dispositivo de inhalación de aerosol que comprende un alojamiento que está adaptado para recibir un recipiente de aerosol (2) que contiene una formulación de medicamento presurizada, una porción de conducto a través de la cual inhala el usuario, un conjunto de boquilla (5) y un orificio (8) que se caracteriza por la presencia de un elemento tubular (11) que se extiende en la porción de conducto desde la abertura del orificio en un eje longitudinal que está alineado con un eje longitudinal de la porción de conducto. En particular, tal elemento tubular está posicionado para encerrar la abertura del orificio dentro de una cavidad. El elemento tubular está configurado de modo tal q
