MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人:
RODRIGUEZ MOSES,WARRINGTON ARTHUR E.,PEASE LARRY R.
申请号：
NZ60960711
公开号：
NZ609607A
申请日:
2011.10.19
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is an isolated human IgM antibody or fragment thereof which specifically binds neurons and protects neurons from cell death and which does not promote remyelination, wherein the antibody or fragment comprises CDR Sequences of: HCDR1 GFTFSTYA (SEQ ID NO: 37) HCDR2 INVGGVTT (SEQ ID NO:38) HCDR3 VRRSGPDRNSSPADF (SEQ ID NO:39) LCDR1 QGIG (SEQ ID NO: 40) LCDR2 TTS (SEQ ID NO:41) LCDR3 QKYNSAPRT (SEQ ID NO: 42) for use in treating or ameliorating diseases or conditions in mammals where nerves are compromised, injured or damaged or are at risk thereof. Also disclosed is the use of said antibody in the manufacture of a medicament for targeting and determining neuron injury, death or damage, or cells at risk thereof, in the CNS in a mammal.
