Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on BTK occupancy and BTK resynthesis rate

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专利权人:

发明人:

LANNUTTI, BRIAN,雷努提 布莱恩,雷努提 布萊恩,COVEY, TODD,克维 陶德,克維 陶德,KAPTEIN, ALLARD,卡特恩 阿拉德,卡特恩 阿拉德,JOHNSON, DAVID,强森 大卫,強森 大衛,STAMATIS, JAY,史塔玛提斯 杰,史塔瑪提斯 傑,KREJSA, CECILE M.,克瑞萨 瑟希尔,克瑞薩 瑟希爾,SLATTER, JOHN GREGORY

申请号：

TW105103868

公开号：

TW201705959A

申请日:

2016.02.04

申请国别(地区):

TW

年份:

2017

代理人:

摘要：

In an embodiment, therapeutic methods and uses of Bruton’s Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.在一實施態樣中,本發明說明布魯頓(Bruton)氏酪胺酸激酶(BTK)抑制劑治療在多種不同疾病、組織室(包括骨髓和淋巴結)中以B細胞之BTK佔據及/或BTK再合成速率為基礎之癌症、發炎、免疫病症和自體免疫病症(包括皮膚病)及移植預防之治療方法及用途。在一實施態樣中,本發明說明BTK抑制劑治療以多種不同疾病、組織室(包括骨髓和淋巴結)中的B細胞之BTK佔據及/或BTK再合成速率為基礎之癌症、發炎、免疫病症和自體免疫病症(包括皮膚病)及移植預防之給藥配置。

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中国工程科技知识中心

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