Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on BTK occupancy and BTK resynthesis rate农业专利-农业专业知识服务系统

发明人:: LANNUTTI, BRIAN,雷努提布莱恩,雷努提布萊恩,COVEY, TODD,克维陶德,克維陶德,KAPTEIN, ALLARD,卡特恩阿拉德,卡特恩阿拉德,JOHNSON, DAVID,强森大卫,強森大衛,STAMATIS, JAY,史塔玛提斯杰,史塔瑪提斯傑,KREJSA, CECILE M.,克瑞萨瑟希尔,克瑞薩瑟希爾,SLATTER, JOHN GREGORY

摘要：: In an embodiment, therapeutic methods and uses of Bruton’s Tyrosine Kinase (BTK) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for a BTK inhibitor for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on BTK occupancies and/or BTK resynthesis rates for B cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described.在一實施態樣中,本發明說明布魯頓(Bruton)氏酪胺酸激酶(BTK)抑制劑治療在多種不同疾病、組織室(包括骨髓和淋巴結)中以B細胞之BTK佔據及/或BTK再合成速率為基礎之癌症、發炎、免疫病症和自體免疫病症(包括皮膚病)及移植預防之治療方法及用途。在一實施態樣中,本發明說明BTK抑制劑治療以多種不同疾病、組織室(包括骨髓和淋巴結)中的B細胞之BTK佔據及/或BTK再合成速率為基礎之癌症、發炎、免疫病症和自體免疫病症(包括皮膚病)及移植預防之給藥配置。