Substrates configured for use with an aerosol agent delivery device to vaporize and deliver an aerosol agent to a user include a carrier and a paste applied to the carrier. The carrier is formed from a non-combustible, thermally conductive, non-toxic and non-off gassing material, such as glass, ceramic or metal. The carrier may be formed in the shape of a solid or porous disc, cupped disc, cylinder or spiral cylinder and the paste may be applied to at least one surface of the carrier. The paste composition may include a binder material, an aerosol agent, such as a therapeutic drug or nicotine, an aerosol forming agent, and an inorganic, inert filler material. The aerosol agent may be derived from an organic plant material, such as ground tobacco, coffee, tea or the like. The aerosol agent may also be provided as a liquid additive, such as liquid nicotine and tobacco flavor.