LINDA N. CASILLAS,MICHAEL P. DMARTINO,JOSHI M. RAMANJULU,ROBERT JR. SINGHAUS,JOHN F. MEHLMANN,PAMELA A. HAILE
申请号：
ARP130103248
公开号：
AR092530A1
申请日:
2013.09.11
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
1. The characteristic is 1: an amino quinine compound with formula characteristic,Wherein: R1 is apartment c8321；halo-C₁₋₆ alkyl,C₃₋₆ cycloalkyl or 4-6 membered heterocycloalkyl, wherein: said C₁₋₆ alkyl is optionally substituted with a group selected from the group consisting of cyano, hydroxyl, C₁₋₆ alkoxy,C₁₋₆ alkoxy C₂₋₆ alkoxy,-CO₂H, -CO₂-alquilo C₁₋₄,-SO₂-alquilo C₁₋₄,1. One or two independently selected groups can be selected to replace 4-6 members of cycloquilo c8332326 and non cyclopentyl glycol；1. Hydroxy, amino, hydrocarbyl c832131；C₁₋₄-C₁₋₄-amino- alkyl,1. Lease of c83218331 and 83242431；1. Hidroxi acquilo c833217d.833183248a and alcoxi c833218d.83312248a；said C₃₋₆ cycloalkyl or 4-6 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from the group consisting of halogen, -CF₃,hydroxyl, cyano, amino, C₁₋₄-amino- alkyl,alquil C -alquil C amino-1. Lease of c83218331 and 83242431；Cxi- hydroxy-alkyl,oxo and C₁₋₄ and R² alkoxy is fluoro, hydroxy, C₁₋₆- alkoxy,hello-alcoxi C₁₋₆-,alcoxi C alcoxi ChaloalkoxyC₁₋₄alkoxyC₂₋₆-,hydroxy C₂₋₆- alkoxy,C₃₋₆-C₁₋₄- alkoxycycloalkyl,C₃₋₆-oxy cycloalkyl,1. Isopropyl (4-6 members) - alcoxi c833213124 or isopropyl (4-6 members) - oxi -,wherein the halo-C alquilo-alkyl moiety of the halo-C₁₋₆-alkoxy and the halo-C resto-alkyl moiety of the halo-C₁₋₄-alkoxy-C₂₋₆-alkoxy groups contain 1, 2 or 3 fluoro atoms, wherein the C₃₋₆ cycloalkyl moiety of the C₃₋₆-cycloalkyl-Cxi- alkoxy or the C₃₋₆- cycloalkoxy group is optionally substituted with a group selected from the group consisting of cyano, halo, hydroxyl, C₁₋₆ alkoxy and C₁₋ alkoxy Coalkoxy C₂₋₆,and wherein the 4-6 membered heterocycloalkyl radical of the 4-6-membered heterocycloalkyl-C₁₋₄-alkoxy- (4-6-membered) -oxy-is optionally substituted with a group selected from the group consisting of cyano, halo, hydroxyl, C₁₋₆ alkoxy and C₁₋₄alkoxy alkoxy；R3: H, methyl； r8308es: H, methyl or trifluoromethyl； r8309es: H or c83218331；o una de sus
