Abreo, Melwyn,Chafev, Mikhail,Chakka, Nagasree,Chowdhury, Sultan,Fu, Jian-Min,Gschwend, Heinz W.,Holladay, Mark W.,Hou, Duanjie,Kamboj, Rajender,Kodumuru, Vishnumurthy,Li, Wenbao,Liu, Shifeng,Raina, V
申请号：
ES10184939
公开号：
ES2568769T3
申请日:
2004.07.29
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** wherein: x and y are each independently 1, 2 or 3, with the proviso that x and y are not both 1； W is -C (O) N (R1) -； -C (O) N [C (O) R1a] -, -N (R1) C (O) N (R1) - or -N (R1) C (O) -； V is -C (O) -, -C (S) -, or -C (R10) H-； each R1 is independently selected from the group consisting of hydrogen； C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of halogen, methyl or trifluoromethyl； and C2-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of methoxy and hydroxy； R1a is selected from the group consisting of hydrogen, C1-C6 alkyl and C3-C15 cycloalkyl； R2 is selected from the group consisting of C1-C12 alkyl, C2-C12 alkenyl, C2-C12 hydroxyalkyl, C2-C12 hydroxyalkenyl, C1-C12 alkoxy, C2-C12 alkoxyalkyl, C3-C12 cycloalkyl, C4-C12 cycloalkylalkyl, C6 aryl -C19, C7-C12 aralkyl, C3-C12 heterocyclyl, C3-C12 heterocyclylalkyl, C1-C12 heteroaryl, and C3-C12 heteroarylalkyl； or R2 is a multi-ring structure having 2 to 4 rings, wherein the rings are independently selected from the group consisting of C3-C12 cycloalkyl, C3-C12 heterocyclyl, C6-C19 aryl and C1-C12 heteroaryl and where some or all rings may be condensed with each other； R3 is selected from the group consisting of C2-C12 alkenyl, C2-C12 hydroxyalkyl, C2-C12 hydroxyalkenyl, C1-C12 alkoxy, C2-C12 alkoxy, C3-C12 cycloalkyl, C4-C12 cycloalkylalkyl, C6-C19 aryl, C7 aralkyl -C12, C3-C12 heterocyclyl, C3-C12 heterocyclylalkyl, C1-C12 heteroaryl and C3-C12 heteroarylalkyl； or R3 is a multi-ring structure having 2 to 4 rings, wherein the rings are independently selected from the group consisting of C3-C12 cycloalkyl, C3-C12 heterocyclyl, C6-C19 aryl and C1-C12 heteroaryl and where some or all rings may be condensed with each other； R4 and R5 are each independently selected from hydrogen, fluoro, chloro, methyl, methoxy, trifluoromethyl, cyano, nitro or -N (R12) 2； R6, R6a, R7, R7a, R8,
