The present invention provides new compounds and methods for treating a disease responsive to inhibition of kinase activity, for example a disease responsive to inhibition of protein tyrosine kinase activity, for example a disease responsive to inhibition of protein tyrosine kinase activity of growth factor receptors, for example a disease responsive to inhibition of receptor type tyrosine kinase signaling, or for example, a disease responsive to inhibition of VEGF receptor signaling.本發明提供用於治療對激酶活性抑制有應答的疾病之新型化合物和方法,例如對蛋白酪氨酸激酶活性之抑制有應答的疾病;例如對生長因數受體之蛋白酪氨酸激酶活性之抑制有應答的疾病;例如對受體類型酪氨酸激酶信號之抑制有應答的疾病;或者例如對VEGF受體信號之抑制有應答的疾病。