Germinated Fermented Soybean Extract Having Effect of Protecting Liver Cells and Increasing Bone Density Containing Coumesterol And Composition Containing The Extract
The present invention relates to a germinated fermented soybean extract containing coumestrol, a manufacturing method thereof and a composition containing the germinated fermented soybean extract. It is confirmed that the germinated fermented soybean extract of the present invention is effective in the hepatocyte protection against hepatotoxicity through in vitro antioxidative activity and cell viability, and hematological tests and MDA, GST, GSH, SOD, and CAT measurements in animal models. In addition, the germinated fermented soybean extract of the present invention increases a mineral content in bones, thereby significantly increasing a bone density, and has an effect of increasing the thickness and number of spongy bones. Furthermore, the germinated fermented soybean extract of the present invention has an effect of relieving symptoms of menopause.본 발명은 쿠메스테롤을 함유하는 발아발효콩 추출물, 그의 제조방법 및 상기 발아발효콩 추출물을 포함하는 조성물에 관한 것이다. 본 발명의 발아발효콩 추출물은 간독성에 대하여 in vitro 항산화활성과 세포생존율 그리고 동물모델의 혈액학적 검사, MDA, GST, GSH, SOD, CAT등의 측정을 통해 간세포 보호에 효과적임을 알 수 있다. 또한 골의 미네랄 함량을 증가시켜 골의 밀도가 유의적으로 증가하며, 해면골의 두께와 수를 증가시키는 효과를 갖는다. 또한 갱년기 증상을 완화시키는 효과가 있다.
