KISS, LASZLO ERNO,GUSMAO DE NORONHA, RITA,ROSA, CARLA PATRICIA DA COSTA PEREIR,PINTO, RUI
申请号：
TW103126395
公开号：
TW201536770A
申请日:
2014.08.01
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
There is provided a compound having Formula I: wherein: R1 is aryl which is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy, or R1 is aryl which is substituted with a second aryl group or an aryloxy group, wherein the second aryl group or the aryloxy group is optionally substituted with one or more groups selected from hydroxyl, halogen and C1-4 alkoxy； R2 is C1-4 alkyl； R3 is selected from hydroxyl and OSO2CH3； R4 and R5 are independently selected from hydrogen, hydroxyl and halogen； and n is 0 or 1； or a pharmaceutically acceptable salt thereof； wherein when R3 is hydroxyl and R4 and R5 are not hydroxyl, the optionally substituted aryl group, second aryl group or aryloxy group of R1 is substituted with one or more hydroxyl groups or C1-4 alkoxy groups, or wherein when R3 is hydroxyl, one of R4 and R5 is hydroxyl, provided that the compound is not N-(1-benzylpiperidin-4-yl)-4-(3,4-dihydroxyphenyl)-N-methyl-1H-imidazole-1-carboxamide hydrobromide. The compound may be used as an inhibitor of fatty acid amide hydrolase.提供有一種具式I之化合物：□其中：R1為芳基，其任擇地被取代以選自羥基、鹵素與C1-4烷氧基之一或多個基團，或R1為芳基，其被取代以一第二芳基或一芳氧基，其中該第二芳基或該芳氧基任擇地被取代以選自羥基、鹵素與C1-4烷氧基之一或多個基團；R2為C1-4烷基；R3係選自羥基與OSO2CH3；R4與R5係獨立地選自氫、羥基與鹵素；以及n為0或1；或其藥學上可接受的鹽類；其中當R3為羥基且R4與R5不為羥基時，R1的該任擇地被取代之芳基、第二芳基或芳氧基被取代以一或多個羥基或C1-4烷氧基，或其中當R3為羥基，R4與R5之一者為羥基時，前提是該化合物不為N-(1-苯甲基哌啶-4-基)-4-(3,4-二羥苯基)-N-甲基-1H-咪唑-1-甲醯胺氫溴酸鹽。該化合物可用作脂肪酸醯胺水解酶抑制劑。
