Duplex Oligonucleotides with Enhanced Functionality in Gene Regulation

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专利权人:

Anastasia Khvorova

发明人:

Anastasia Khvorova,Devin Leake,Barbara Robertson,Annaleen Vermeulen,Christina Yamada

申请号：

US13460026

公开号：

US20120259001A1

申请日:

2012.04.30

申请国别(地区):

US

年份:

2012

代理人:

摘要：

Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions.

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中国工程科技知识中心

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http://www.ckcest.cn/home/