The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. As a result a thick transparent and mechanically strong collagen based composition was formed. This cyclodextrin collagen composition holds a great potential to be used as a therapeutic eye patch for corneal repair. Methods for making these inventive compositions and their use are also provided.
