Diagnosis-treatment Integrated nano-probe for 19F-MR/fluorescence multi-mode molecular imaging and drug-loading and preparation method and application of nano-probe
Xilin SUN,Lina WU,Jie YANG,Kai WANG,Lili YANG,Haoxiang LI,Yingbo LI,Xiaona LI,Shuang LIU
申请号：
US16856432
公开号：
US20200261604A1
申请日:
2020.04.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention provides a 19F-MR/fluorescence multi-mode molecular imaging and drug loading diagnosis-treatment integrated nanoprobe, and a preparation method and an application. The nano-probe is a nanoparticle formed by coating a mixture of a surfactant containing a molecular targeting treatment drug and a fluorescent dye with a Perfluorocarbon (PFC) carrier； and by uniformly dispersing a mixed solution into water and glycerol, processing ultrasonically, removing a component which is not effectively coated, and purifying, the drug-loading nanoparticle capable of being used for 19 F-MR imaging may be prepared. The nano-probe may implement in-vivo 19F-MR molecular imaging； a carried molecular targeting treatment drug can implement targeted binding and targeted treatment； and by virtue of a characteristic that PFC in a nucleus may carry and release oxygen massively, an anaerobious microenvironment in the tumor is improved, a chemosensitization effect is achieved, and thus the diagnosis-treatment integration of the tumor is implemented finally.
