Kayla Nalynn Green,Kimberly Marie Lincoln,Paulina Gonzalez
申请号：
US14105435
公开号：
US20140206861A1
申请日:
2013.12.13
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Amine chelates capable of antioxidant capacity and amyloid disaggregation are shown which may be useful in targeting metal-based oxidative stress in neurodegenerative disorders. Pyclen, a backbone commonly investigated for contrast agent imaging, may be repurposed as an anti-oxidant chelator for disaggregating amyloid. The antioxidant capacity of pyclen was enhanced dramatically via conversion of the pyridine backbone to a pyridol with cellular studies showing superior antioxidant capacity while retaining chelation ability to protect amyloid from metal ions aggregation and also disaggregate amyloid aggregates.
