MARRUGAT DE LA IGLESIA JAUME,ELOSUA LLANOS ROBERTO,SALGADO GOMEZ JOAN,SALAS PEREZ-RASILLA EDUARDO,CASTILLO FERNANDEZ SERGIO,ORDOVAS MUOZ JOSE MARIA
申请号：
ARP120102838
公开号：
AR087445A1
申请日:
2012.08.03
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
It refers to a method of risk assessment for an object, which is more appropriate than the risk assessment algorithm, such as but not limited to Framingham, regicor, score, proclar, QRISK,According to the existence of different polymorphism. It also involves a method to determine the risk of cardiovascular disease, that is, the lack or presence of one or more pathological markers in the sample of experimental subjects, the combination of conventional CVD risk factors and computer-aided means. Method. 1: a method for assessing the cardiovascular risk of an object, or for reclassifying an object from an improved risk assessment, compared with the results obtained by using the scale / method of such risk assessment, such as but not limited to:Framingham, Regicor, Score, Procamor, Qrisk, characterized in that it comprises the steps of determining in a sample isolated from said subject the presence of polymorphisms at positions 27 within the nucleic acid sequences of SEQ ID NOS: 1-34, where the presence in position 27 of a C in SEQ ID No. 1, C in SEQ ID No. 2, T in SEQ ID No. 3, C in SEQ ID No. 4, C in SEQ ID No. 5, C in SEQ ID No. 6, T in SEQ ID No. 7, G in SEQ ID No. 8, A in SEQ ID No. 9, A in SEQ ID No. 10, A in SEQ ID No. 11, G in SEQ ID. No. 12, A in SEQ ID No. 13, C in SEQ ID No. 14, G in SEQ ID No. 15, A in SEQ ID No. 16, A in SEQ ID No. 17,G in SEQ ID No. 18, C in SEQ ID No. 19, T in SEQ ID No. 20, A in SEQ ID No. 21, G in SEQ ID No. 22, C in SEQ ID No. 23, C in SEQ ID No. 24, G in SEQ ID No. 25, C in SEQ ID No. 26, A in SEQ ID No. 27, C in SEQ ID No. 28, G in SEQ ID No. 29, T in SEQ ID No. 30, T in SEQ ID No. 31, C in SEQ ID No. 32, C in SEQ ID No. 33 and / or C in SEQ ID No. 34 is indicative of a risk of having a cardiovascular event.Se refiere a un método para la reclasificación de un sujeto para una evaluación del riesgo más apropiada que la obtenida usando los algoritmos para esa estimación de riesgos tal como, pero no limitada a, Framingham, Regicor, Score,
