ZHEJIANG MEDICINE CO.; LTD. XINCHANG PHARMACEUTICAL FACTORY
发明人:
申请号：
EP10750304.7
公开号：
EP2407153B1
申请日:
2010.03.04
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention relates to a method of preparing for an oil suspension of carotenoid with low viscosity and high fluidity and use thereof. The method comprises the following steps: mixing carotenoid crystals with tetrahydrofuran, heating the mixture to reflux temperature 50ˆ¼70°C under stirring to dissolve the crystal, filtering and condensing to obtain the concentrate； mixing the concentrate with ketone solvent, heating the mixture to reflux temperature 60ˆ¼800–¡ to dissolve the concentrate, filtering, condensing, adding absolute alcohol, crystallizing under stirring at room temperature, filtering and drying in vacuum to obtain carotenoid crystals； mixing carotenoids crystals after granded with plant oil or grinding carotenoid crystals with plant oils and then adding plant oil, to obtain the oil suspension of carotenoid with low viscosity and high fluidity. While the content of carotenoid is 10.0ˆ¼45.0wt.% in the oil suspension of carotenoid obtained from the present invention, the oil suspension of carotenoid has high fluidity at temperature 5ˆ¼25°C, and in the meanwhile do not need any extra heating steps during applications.
